Daniel D Von Hoff Selected Research

130-nm albumin-bound paclitaxel

1/2020	Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma.
1/2020	Nomogram for Estimating Overall Survival in Patients With Metastatic Pancreatic Cancer.
10/2019	Response Rate Following Albumin-Bound Paclitaxel Plus Gemcitabine Plus Cisplatin Treatment Among Patients With Advanced Pancreatic Cancer: A Phase 1b/2 Pilot Clinical Trial.
7/2019	Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial.
1/2019	A Phase Ib/II Study of the JAK1 Inhibitor, Itacitinib, plus nab-Paclitaxel and Gemcitabine in Advanced Solid Tumors.
1/2018	Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors.
8/2017	18F-FDG PET/CT response in a phase 1/2 trial of nab-paclitaxel plus gemcitabine for advanced pancreatic cancer.
6/2017	Letter to the Editor Re: Ahn DH, Krishna K, Blazer M, et al. "A modified regimen of biweekly gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer is both tolerable and effective: a retrospective analysis." Ther Adv Med Oncol https://doi.org/10.1177/1758834016676011.
1/2017	Tumor Reduction in Primary and Metastatic Pancreatic Cancer Lesions With nab-Paclitaxel and Gemcitabine: An Exploratory Analysis From a Phase 3 Study.
10/2016	Second-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer.

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Daniel D Von Hoff Research Topics

Disease

113	Neoplasms (Cancer) 11/2021 - 01/2002
70	Pancreatic Neoplasms (Pancreatic Cancer) 12/2021 - 03/2002
29	Adenocarcinoma 01/2021 - 07/2007
10	Neoplasm Metastasis (Metastasis) 01/2020 - 04/2007
8	Carcinogenesis 01/2019 - 03/2003
8	Neutropenia 01/2019 - 11/2003
7	Disease Progression 12/2014 - 07/2006
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2021 - 10/2011
5	Hypoxia (Hypoxemia) 10/2018 - 03/2008
4	Breast Neoplasms (Breast Cancer) 11/2021 - 08/2002
4	Fatigue 02/2016 - 09/2009
4	Ovarian Neoplasms (Ovarian Cancer) 07/2014 - 11/2005
4	Colorectal Neoplasms (Colorectal Cancer) 06/2014 - 03/2003
3	Diarrhea 01/2020 - 01/2013
3	Thrombocytopenia (Thrombopenia) 01/2019 - 11/2003
3	Melanoma (Melanoma, Malignant) 01/2018 - 07/2002
3	Pain (Aches) 01/2016 - 09/2006
3	Carcinoma (Carcinomatosis) 01/2016 - 08/2002
2	Inflammation (Inflammations) 01/2019 - 01/2016
2	Vomiting 02/2016 - 12/2012
2	Giant Cell Tumor of Tendon Sheath 01/2016 - 07/2015
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2016 - 10/2013
2	Malignant Mesothelioma 09/2014 - 10/2011
2	Lymphoma (Lymphomas) 07/2014 - 10/2013
2	Colonic Neoplasms (Colon Cancer) 06/2013 - 07/2009
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 11/2011
2	Basal Cell Carcinoma (Rodent Ulcer) 10/2011 - 09/2009
2	Medulloblastoma 04/2011 - 09/2009
1	Triple Negative Breast Neoplasms 11/2021

Drug/Important Bio-Agent (IBA)

41	Gemcitabine FDA Link 01/2020 - 11/2002
23	130-nm albumin-bound paclitaxelIBA 01/2020 - 12/2011
22	Pharmaceutical PreparationsIBA 01/2020 - 05/2002
19	Proteins (Proteins, Gene)FDA Link 11/2020 - 04/2004
16	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 11/2006
11	Phosphotransferases (Kinase)IBA 01/2017 - 03/2002
10	Small Interfering RNA (siRNA)IBA 02/2012 - 01/2008
8	Biomarkers (Surrogate Marker)IBA 01/2021 - 11/2005
6	CollagenIBA 11/2020 - 07/2015
6	Messenger RNA (mRNA)IBA 11/2020 - 05/2002
6	HhAntag691IBA 01/2020 - 09/2009
6	Albumin-Bound Paclitaxel FDA Link 10/2019 - 11/2005
6	Biological ProductsIBA 01/2019 - 02/2008
6	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2017 - 07/2007
5	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 10/2011
5	Irinotecan (Camptosar)FDA LinkGeneric 01/2019 - 01/2013
5	Hyaluronic Acid (Hyaluronan)IBA 10/2018 - 09/2011
5	Antineoplastic Agents (Antineoplastics)IBA 01/2017 - 08/2002
4	PlatinumIBA 10/2019 - 03/2008
4	Cisplatin (Platino)FDA LinkGeneric 10/2019 - 10/2011
4	Leucovorin (Folinic Acid)FDA Link 01/2019 - 02/2016
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2018 - 11/2002
4	OligonucleotidesIBA 01/2012 - 01/2008
3	NucleotidesIBA 01/2021 - 04/2004
3	N- (3,4- difluoro- 2- (2- fluoro- 4- iodophenylamino)- 6- methoxyphenyl)- 1- (2,3- dihydroxypropyl)cyclopropane- 1- sulfonamideIBA 12/2020 - 05/2011
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2020 - 05/2011
3	AlbuminsIBA 01/2020 - 11/2005
3	EnzymesIBA 01/2019 - 07/2002
3	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2018 - 10/2011
3	Cdc25C phosphatase (211-221)IBA 09/2017 - 10/2011
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2016 - 11/2005
3	Antisense OligonucleotidesIBA 06/2013 - 05/2004
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2004 - 03/2003
2	copanlisibIBA 12/2020 - 01/2020
2	ChromatinIBA 11/2020 - 10/2020
2	triptolideIBA 11/2020 - 01/2019
2	Drug CombinationsIBA 01/2020 - 04/2012
2	RNA (Ribonucleic Acid)IBA 01/2020 - 12/2011
2	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 07/2019 - 08/2014
2	CytokinesIBA 01/2019 - 10/2018
2	ProdrugsIBA 01/2019 - 01/2017
2	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 10/2018 - 09/2011
2	PEGPH20IBA 10/2018 - 01/2018
2	Azacitidine (5 Azacytidine)FDA Link 01/2018 - 11/2011
2	Polo-Like Kinase 1IBA 01/2018 - 05/2004
2	Interleukin-6 (Interleukin 6)IBA 09/2017 - 04/2012
2	Macrophage Colony-Stimulating FactorIBA 01/2016 - 07/2015
2	Docetaxel (Taxotere)FDA Link 01/2016 - 02/2015
2	Cysteine (L-Cysteine)FDA Link 07/2015 - 11/2005
2	Temozolomide (Temodar)FDA LinkGeneric 02/2015 - 03/2004
2	LigandsIBA 12/2014 - 09/2008
2	Matrix Metalloproteinases (MMPs)IBA 10/2014 - 12/2011
2	CaspasesIBA 06/2013 - 03/2002
2	AndrogensIBA 01/2013 - 11/2011
2	ErbB Receptors (EGF Receptor)IBA 04/2012 - 05/2011
2	Lapatinib (GW572016)FDA Link 04/2012 - 04/2010
2	Aurora KinasesIBA 02/2012 - 03/2003
2	Peptides (Polypeptides)IBA 02/2012 - 12/2011
2	AgarIBA 01/2012 - 11/2009
2	ThioredoxinsIBA 03/2011 - 03/2008
2	UA 62784IBA 07/2009 - 01/2009
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2008 - 11/2005
2	Complementary DNA (cDNA)IBA 01/2008 - 05/2002
1	IsotopesIBA 11/2021
1	Pyruvic Acid (Pyruvate)IBA 11/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2021
1	Amino Acids FDA Link 11/2021
1	ribose-5-phosphateIBA 11/2021
1	Glucose (Dextrose)FDA LinkGeneric 11/2021

Therapy/Procedure

47	Therapeutics 12/2021 - 04/2006
12	Drug Therapy (Chemotherapy) 01/2020 - 04/2008